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The spookily random way of life of a virus balance to assail has been enamour on television .
Using a new microscopy technique , researchers at Duke University in Durham , North Carolina have visualized a virus bouncing around the enteric liner , looking for entry into a cell .
A still from the first real-time footage of viruses on the move, right before they hijack a cell. Captured by researchers at Duke University.
To use a home - invasion metaphor , the second captured on TV " would be the part where the burglar has not broken the window yet,“Courtney " CJ " Johnson , an associate at the Howard Hughes Medical Institute ’s Janelia Research Campus in Ashburn , Virginia , who convey the research while gain her doctorate at Duke , said in a argument .
computer virus are everywhere , and the consistence has evolved a phone number of barriers to keep them from strive the interior of cells , where viruses can apply the cellular machinery to create more written matter of themselves , sparking an infection . In the bowel , a layer of protective , mucus - release cells keep virus at true laurel , but these defenses sometimes break down .
" How do viruses navigate these complex barriers?“Kevin Welsher , an assistant prof of alchemy at Duke who co - authored the research , said in the statement .
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Peering into this process is no simple matter . virus are hundreds of multiplication humble than cells , making visualise both at the same time very difficult — like taking a picture of a complete skyscraper and a person stand in front of it at the same sentence , Johnson enjoin . virus also move very speedily when they ’re outdoors of cells .
To defeat these issues , the researchers developed a new method acting that coalesce two microscopes . First , they " tag " a virus with a fluorescent chemical compound . A tracking microscope then sweeps a laser across the dog computer virus Holy Order to update the position of the virus every millionth of a second . This all happens on a moving weapons platform so that the microscope can keep the computer virus in focal point .
Meanwhile , the second microscope take three - dimensional picture of the cell around the virus . This microscope also uses lasers to keep the background image from blurring as the microscopic program displacement around .
The computer virus in the video recording is not a natural virus , but a non - infectious lentivirus — a genus of retroviruses with recollective incubation periods — outwear the exterior of a vesicular stomatitis computer virus . A real vesicular stomatitis computer virus causes balmy fever in humankind and other creature .
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The video recording shows the virus skitter randomly over the surface of the surrounding electric cell . It from time to time break into a welcoming receptor and binds to the cell control surface , but this does n’t immediately point that an infection is underway ; often , the virus detaches and bounce away .
So far , the researcher can only go after a viral atom for a few minutes before the fluorescent compound fatigue forth and the particle goes inconspicuous . It will take a trailing clip of tens of minute to conform to a virus through the intact outgrowth of skimming , binding , and infecting a cellular phone , the research worker reported Nov. 10 in the journalNature Methods . The researchers are working to modernize brighter , longer - lasting trailing compounds so that they can fancy viruses in increasingly more realistic cellular environments over longer flow of time .
" This is the real promise of this method acting , " Welsher enunciate . " We think that ’s something we have the possible action to do now . "
